Contributions to the Research & Society
My laboratory focuses on the molecular origins of human
cancer. More specifically, my laboratory has 3 inter-related
research objectives based on the underlying concept that
developing an in-depth understanding of epigenetic mechanisms
in human cells will allow for the development of more effective
strategies for the prevention, treatment, and cure of cancer.
First, we wish to identify which epigenetic mechanisms
participate in the transcriptional control of genes important
to growth and differentiation. Second, we seek to determine
how these epigenetic mechanisms, and therefore epigenetic
homeostasis, become compromised during oncogenesis leading
to genomic dysfunction. Third, using our new and more complete
understanding of epigenetic control of the genome, we are
developing rational new therapeutic strategies that seek
to repair these defects and transcriptionally reprogram
the malignant cancer cell to a benign state.
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