My laboratory focuses on the molecular origins of human cancer. More specifically, my laboratory has 3 inter-related research objectives based on the underlying concept that developing an in-depth understanding of epigenetic mechanisms in human cells will allow for the development of more effective strategies for the prevention, treatment, and cure of cancer. First, we wish to identify which epigenetic mechanisms participate in the transcriptional control of genes important to growth and differentiation. Second, we seek to determine how these epigenetic mechanisms, and therefore epigenetic homeostasis, become compromised during oncogenesis leading to genomic dysfunction. Third, using our new and more complete understanding of epigenetic control of the genome, we are developing rational new therapeutic strategies that seek to repair these defects and transcriptionally reprogram the malignant cancer cell to a benign state.