The studies of ovarian toxicity are relevant to the ability of environmental chemicals to cause an early onset of menopause in women. This is important because menopause is known to be associated with increased risks for a number of disorders such as cardiovascular disease, osteoporosis, Alzheimer’s disease, and depression. Thus, undergoing early menopause would expose a woman to more years with these increased health risks. The mouse model for menopause will be useful to researchers studying menopause-associated diseases as well as to pharmaceutical companies developing ideal formulations of drugs for treatment of menopause-associated conditions or for hormone replacement therapy.