Terrence J. Monks, Ph.D.
Professor Pharmacology & Toxicology
Chair, Dept. of Pharmacology of Toxicology

College Of Pharmacy, Rm. 238A
1703 E. Mabel St.,
Tucson, AZ 85721.
Telephone: (520) 626-9906
Fax: (520) 626-2466
Emial: monks@pharmacy.arizona.edu

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Contributions to the Research & Society

Little is known about the ability of ROS to alter chromatin or histones. Dr. Monks has shown that ROS activate MAPKs, and promote the phosphorylation of histone H3 which is required for the initiation of chromosome condensation, a process essential for mitosis. Manipulations that inhibit H3 phosphorylation are coupled to decreases in chromatin condensation, and to increases in cell survival.

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